Bid guide
How to bid on preclinical animal research for NIH
What the NIH is buying and why it matters
The National Institutes of Health (NIH) is seeking preclinical animal research services. The goal is to investigate if inhibiting soluble adenylyl cyclase (sAC) can help improve pulmonary arterial hypertension (PAH). This research will use a specific mouse model, the endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine model, along with wild-type controls.
This opportunity is for vendors who can provide specialized animal research services, particularly those with expertise in cardiovascular and pulmonary diseases and specific animal models.
Key dates and what happens at the deadline
This notice was published on September 13, 2026. The deadline for submitting information for consideration is September 21, 2026, at 12:00 PM ET. At this deadline, the NIH will review any submitted capability statements or quotations.
The NIH intends to award this contract on a sole-source basis to the University of Illinois at Chicago (UIC). However, other capable sources are invited to submit information for consideration.
Who this opportunity suits
This opportunity is best suited for research institutions or specialized contract research organizations (CROs) that possess an established endothelial cell-specific Cav1 knockout mouse colony. The NIH states that this specific mouse model is currently maintained by UIC and is not known to be available from other laboratories.
Firms with strong capabilities in preclinical animal research, particularly in pulmonary arterial hypertension and related cardiovascular research, and who can demonstrate access to or the ability to replicate the required animal model, should consider responding.
How to respond
To access the full details and instructions, you need to view the original source on the portal. Click the “View original source” link. If the first click takes you to the portal's homepage, click it again to go directly to the bid.
You may need to create a free account on the portal to view all documents, though this is not always required. Once you have reviewed the full description, basis for the intended sole-source acquisition, and response instructions, you can prepare your submission.
Tips for preparing a competitive response
Even though this is an intent to sole-source, a strong capability statement can still be considered. Clearly articulate how your organization meets or exceeds the specific requirements outlined in the solicitation. Focus on demonstrating your unique ability to perform the work, especially regarding the specialized EC-Cav1 KO mouse colony.
Highlight your expertise in pulmonary arterial hypertension research and preclinical animal models. Provide concrete examples of past performance on similar projects. Ensure your submission directly addresses why your firm is a responsible source that can satisfy the government's requirements, despite the stated sole-source intent.
See the live bid — deadline, agency details, and how to respond
Dates and requirements can change via addenda; always verify on the bid page and at the original source before responding.
View this bid on BiddingSimpleThis guide was prepared by BiddingSimple from the solicitation’s public posting. It is not official guidance from National Institutes of Health; the original posting controls.