How to bid on Protein ENGineering (PENG) for the DEPT of Defense

What the agency is buying and why it matters

The Defense Advanced Research Projects Agency (DARPA) is looking for proposals to develop a Protein ENGineering (PENG) program. This program aims to create a programmable platform for precisely editing naturally occurring proteins.

The goal is to move protein engineering from individual tools to a universal, software-defined discipline. This work involves building a platform with modular targeting, generalizable effector chemistries, and multiplexed control systems. It may include exploring novel splicing, ligation, and co-translational techniques to modify proteins within complex biological systems. The platform will be tested in high-fidelity cellular models like organoids.

Key dates and what happens at the deadline

This opportunity was published on August 21, 2026. The deadline for submitting proposals is October 19, 2026, at 12:00 PM ET. All proposals must be submitted by this time.

Who this opportunity suits

This opportunity is suitable for firms with expertise in professional services related to advanced biological research, protein engineering, molecular biology, and cellular model development. Companies capable of developing innovative, integrated platforms for precise protein modification within complex biological architectures would be a good fit.

How to respond

To access the solicitation, click “View original source” on the portal. If the first click takes you to the portal’s homepage, click it again to go directly to the bid. You may need a free account on the portal to view all documents, though this is not always required for every bid.

Practical tips for preparing a competitive response

Focus your proposal on demonstrating a clear understanding of the technical requirements for a multifunctional, target-agnostic platform. Highlight your firm's capabilities in modular targeting, effector chemistries, and multiplexed control systems. Clearly outline your proposed technical path, including how you will progressively advance approaches from foundational validation to robust demonstrations of efficacy.

Emphasize your experience with high-fidelity cellular models, such as organoids, for validating the integrated platform. Provide concrete examples of past work that showcases your ability to integrate novel splicing, ligation, and co-translational techniques. Ensure your proposal clearly articulates how your approach will transition proteome engineering into a universal, software-defined discipline.