Professional & Consulting
Opportunity timeline
PostedAug 21, 2026
DeadlineOct 19, 2026
In plain English
DARPA is seeking proposals to build a programmable platform for precisely editing naturally occurring proteins. The work may include protein targeting, splicing, ligation, co-translational methods, and multiplexed controls, with testing progressing to complex cell models such as organoids. Multiple technical approaches may be pursued.
About this opportunity
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational…
Time remaining
Closes Oct 19, 2026
35Days
:07Hours
:42Min
:51Sec
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Ref No.
BS-51B076