How to bid on TIDAL: Target-Induced Droplet Assembly of Ligands from Los Alamos National Laboratory

What Los Alamos National Laboratory is offering

Los Alamos National Laboratory is making available a technology called TIDAL (Target-Induced Droplet Assembly of Ligands). This is a protein-only technology that uses small antibody fragments, called nanobodies, to form target-triggered droplets. The technology is at TRL 3 and has a U.S. patent pending.

TIDAL has potential applications in several areas, including resin-free protein purification, slow-release drug delivery, intracellular protein trapping, and more sensitive diagnostics. This is an opportunity for companies to acquire licensing agreements, either exclusive or non-exclusive, to use this technology. It is not a request for outside development services.

Key dates and what happens at the deadline

This opportunity was published on September 08, 2026. The deadline for expressing interest is December 08, 2026, at 7:00 PM ET. This deadline is when the window for engaging with Los Alamos National Laboratory regarding licensing this technology will close.

Who this opportunity suits

This opportunity is suitable for companies in the professional services category, particularly those in biopharmaceutical manufacturing, therapeutics and drug delivery, diagnostics, biotechnology, or reagent development. Firms looking to enhance their product lines or manufacturing processes with innovative protein-based solutions would find this relevant.

Companies interested in licensing new technologies for applications such as antibody and enzyme purification, subcutaneous slow-release treatments, high-sensitivity detection assays, or resin-free enzyme immobilization are well-suited for this offering.

How to respond

To access the original source for this opportunity, you will need to click the “View original source” button. If the first click takes you to the portal’s homepage, click it again to go directly to the bid details.

You may need to create a free account on the portal to view all associated documents, though for some bids, this may not be necessary. For specific discussions regarding licensing, you should contact [email protected].

Practical tips for preparing a competitive response

When considering a licensing agreement for a technology like TIDAL, clearly articulate how your company plans to commercialize the innovation. Highlight your market expertise and how TIDAL aligns with your existing product lines or strategic goals.

Demonstrate a clear understanding of the technology's advantages, such as its ability to cut purification costs or boost diagnostic sensitivity. Outline your proposed applications and how they leverage TIDAL's unique features. Provide a realistic timeline and resources you would dedicate to bringing the licensed technology to market.