How to bid on SHINE neuroplasticity research for DARPA

What DARPA is buying and why it matters

The Defense Advanced Research Projects Agency (DARPA) is looking for innovative basic or applied research concepts related to targeted neuroplasticity. This initiative is called the Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE) Disruption Opportunity.

This is an opportunity for researchers to contribute to advanced scientific understanding in a critical area, with potential for significant impact. Awards will be made as Other Transaction for Prototype Agreements, with each award capped at $2 million. This total includes both government funding and any performer cost share.

Key dates and what happens at the deadline

This opportunity was published on September 03, 2026. All submissions must be received by October 09, 2026, at 12:00 PM ET. It is important to submit your proposal before this exact deadline, as late submissions are typically not accepted.

Who this opportunity suits

This opportunity is suitable for organizations and researchers involved in professional scientific research, particularly those with expertise in neuroscience, neuroplasticity, and related fields. Firms capable of conducting innovative basic or applied research are encouraged to consider this solicitation.

How to respond to this solicitation

To access the full details and prepare your response, you will need to view the original source document. Click the “View original source” link. If the first click takes you to the portal's homepage, click the link a second time to go directly to the bid.

You may need to create a free account on the portal to view all associated documents, though for some bids, this step is not required.

Tips for preparing a competitive response

When preparing your submission, clearly articulate the innovative aspects of your research concept and how it addresses targeted neuroplasticity. Ensure your proposal aligns with the scope of basic or applied research as described by DARPA.

Pay close attention to the budget, ensuring your proposed costs, including any cost share, do not exceed the $2 million per award limit. Clearly outline your methodology, expected outcomes, and the potential impact of your research. A well-structured and concise proposal that highlights your team's capabilities will be key.