Bid guide
How to bid on Generative Unconstrained Intelligence Drug Engineering (GUIDE) with the Dept of the Army
What the Army is buying and why it matters
The Department of the Army is seeking partners for its Generative Unconstrained Intelligence Drug Engineering (GUIDE) program. This initiative uses advanced computing and machine learning to accelerate the development of medical countermeasures, such as antibodies, vaccines, and small molecule drugs. The goal is to protect warfighters from diverse threats.
This is an opportunity for organizations with expertise in medical countermeasure development to collaborate with the Army on cutting-edge research and development. Participation could lead to projects awarded under specific authorities, outside of standard FAR regulations.
Key dates and what happens at the deadline
This special announcement was published on June 13, 2025. The deadline for submitting your request to participate is October 18, 2028, at 12:00 PM ET.
At the deadline, the Army will review all submitted requests for participation. They will assess your technical relevance to the GUIDE program to determine if you will be invited to participate as a qualified entity.
Who this opportunity suits
This opportunity is suitable for organizations with technical expertise and recent experience in the development of medical countermeasures. This includes firms specializing in biological products like monoclonal antibodies and vaccines, as well as small molecule drugs.
The Army is looking for U.S. interagency, academic, and industry partners. If your firm has capabilities in advanced simulation and machine learning applied to drug discovery and design, this program aligns with your strengths.
How to respond
To express your interest, you must send an email requesting participation to the primary points of contact listed in the solicitation. Your email should clearly demonstrate your technical relevancy and recent experience in developing medical countermeasures. Avoid sending only advertisement or marketing material.
You will need to be registered in the System for Award Management (SAM) database prior to submitting an invoice and through final payment of any agreement. If you are not registered, you should apply for registration immediately and ensure your SAM information is current and accurate annually.
Practical tips for preparing a competitive response
When drafting your email, focus on specific examples of your technical expertise and past successes in medical countermeasure development. Clearly articulate how your capabilities align with the GUIDE program's objectives, such as optimizing safety, efficacy, manufacturability, and pharmacokinetics/pharmacodynamics.
Ensure your request highlights how your firm can contribute to accelerating medical countermeasure development using advanced simulation and machine learning. Emphasize any experience with similar programs or technologies that demonstrate your ability to contribute to an integrated computational and experimental platform.
See the live bid — deadline, agency details, and how to respond
Dates and requirements can change via addenda; always verify on the bid page and at the original source before responding.
View this bid on BiddingSimpleThis guide was prepared by BiddingSimple from the solicitation’s public posting. It is not official guidance from Dept of the Army; the original posting controls.