How to bid on Protein ENGineering (PENG) for the DEPT of Defense

What the agency is buying and why it matters

The Defense Advanced Research Projects Agency (DARPA) is looking for research proposals for its Protein ENGineering (PENG) program. The goal is to create a programmable platform that can precisely edit naturally occurring proteins. This work aims to move proteome engineering from specialized tools to a universal, software-defined field.

DARPA wants a comprehensive platform that combines modular targeting, generalizable chemistry, and multiplexed control systems. This means developing integrated techniques for splicing, ligation, and co-translational methods to recognize, modify, and rewrite proteins within complex biological structures. The platform should be validated in high-fidelity cellular models, such as organoids.

Key dates and what happens at the deadline

This solicitation was published on August 07, 2026. Proposals are due by October 19, 2026, at 12:00 PM ET. All submissions must be completed by this deadline.

Who this opportunity suits

This opportunity is suitable for research organizations, biotechnology firms, and academic institutions with expertise in protein engineering, synthetic biology, and advanced biological platforms. Firms specializing in developing innovative tools for protein modification and cellular systems will find this relevant. This falls under the professional services category, specifically advanced research and development in life sciences.

How to respond to this solicitation

To access the full solicitation details and prepare your response, you need to go to the original source on the portal. Click the “View original source” link. If the first click takes you to the portal’s homepage, click the link again to go directly to the bid. You may need to create a free account on the portal to view all documents, though this is not always required for every bid.

Tips for preparing a competitive response

When preparing your proposal, clearly outline your technical approach for integrating modular targeting, effector chemistries, and multiplexed control systems. Emphasize how your proposed platform will move beyond isolated tools to a universal, software-defined discipline. Detail your plan for progressive validation, from foundational stages to robust demonstrations in complex cellular models like organoids.

Ensure your proposal clearly articulates the innovative aspects of your approach and how it addresses DARPA's goal of precise, programmable editing of endogenous proteins. Highlight your team's expertise and any relevant past performance in protein engineering or related fields. Pay close attention to all instructions and requirements in the official solicitation documents once you access them.