How to bid on Medicinal Chemistry Support for Therapeutic Development for NIH

What the NIH is buying and why it matters

The National Institutes of Health (NIH) is looking for medicinal chemistry support. Specifically, they need help synthesizing HERV-K protease inhibitors. This work is part of therapeutic development efforts.

This opportunity is a Firm-Fixed-Price contract, and the NIH intends to award it to the offeror whose proposal offers the best value to the government. The acquisition is not expected to exceed $350,000.00.

Key dates and what happens at the deadline

All responses must be received by August 10, 2026, at 9:00 AM ET. This is a firm deadline, and late submissions may not be considered. Your response must reference solicitation number 75N98026Q00906.

After the deadline, the government will evaluate proposals based on technical capability, price, past performance, and delivery schedule. The NIH reserves the right to accept any offer before the expiration date, and a written notice of award will create a binding contract.

Who this opportunity suits

This opportunity is suitable for firms with expertise in medicinal chemistry and the synthesis of protease inhibitors. The NAICS code associated with this requirement is 541380.

This is a full and open competition, meaning it is not set aside for small businesses. Any responsible offeror capable of providing the required services may submit a proposal.

How to respond to this solicitation

To access the solicitation, click “View original source” on the portal. If you land on the homepage, click it again to go directly to the bid. You may need a free account to view documents, though this is not always required.

Responses must be submitted electronically to [email protected]. Your submission must include your Unique Entity Identifier (UEI), Taxpayer Identification Number (TIN), and business size certification. You must also be actively registered in the System for Award Management (SAM) at www.sam.gov.

Practical tips for preparing a competitive response

Ensure your proposal clearly demonstrates your technical capability to synthesize HERV-K protease inhibitors. Provide sufficient detail to show your understanding of the requirements and your approach.

Carefully review and complete FAR 52.212-3, Offeror Representations and Certifications—Commercial Items, and include it with your offer. Also, ensure your pricing is competitive and includes all unit and total prices, shipping and handling costs, and delivery terms.

Highlight your past performance on similar projects. If you have experience with therapeutic development or working with government agencies, emphasize these points in your response. Clearly state your proposed delivery timeframe after award.